The next door neighbors Nell Bedworth and Woody Deane have opposite behaviors and hate each other: the virgin geek Nell is polite, sensitive and well-prepared to go to Yale, while Woody is rude and his greatest expectation is to join a mediocre university due to his abilities playing football. When Nell and Woody are assigned to visit a museum together, they argue in front of a statue of an Aztec god. During the night, their souls swap bodies, bringing difficult situations to them. They first try to damage each others reputation in high school, but soon they discover that their dream of joining college can only happen with mutual respect and support.